Abstract
Latency-associated peptide of transforming growth factor beta (TGF-beta) (LAP) was used to determine whether in vivo modulation of TGF-beta bioactivity enhanced pulmonary immunity to Mycobacterium bovis BCG infection in C57BL/6 mice. LAP decreased BCG growth in the lung and enhanced antigen-specific T-cell proliferation and gamma interferon mRNA expression. Thus, susceptibility of the lung to primary BCG infection may be partially mediated by the immunosuppressive effects of TGF-beta.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Female
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Interferon-gamma / biosynthesis
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Interferon-gamma / genetics
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Lung / immunology*
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Lung / microbiology*
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Lymphocyte Activation
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Mice
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Mice, Inbred C57BL
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Mycobacterium bovis / immunology*
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RNA, Messenger / analysis
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T-Lymphocytes / immunology
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Transforming Growth Factor beta / physiology*
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Tuberculosis / immunology*
Substances
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RNA, Messenger
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Transforming Growth Factor beta
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Interferon-gamma