Latency-associated peptide of transforming growth factor beta enhances mycobacteriocidal immunity in the lung during Mycobacterium bovis BCG infection in C57BL/6 mice

Infect Immun. 2000 Nov;68(11):6505-8. doi: 10.1128/IAI.68.11.6505-6508.2000.

Abstract

Latency-associated peptide of transforming growth factor beta (TGF-beta) (LAP) was used to determine whether in vivo modulation of TGF-beta bioactivity enhanced pulmonary immunity to Mycobacterium bovis BCG infection in C57BL/6 mice. LAP decreased BCG growth in the lung and enhanced antigen-specific T-cell proliferation and gamma interferon mRNA expression. Thus, susceptibility of the lung to primary BCG infection may be partially mediated by the immunosuppressive effects of TGF-beta.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Female
  • Interferon-gamma / biosynthesis
  • Interferon-gamma / genetics
  • Lung / immunology*
  • Lung / microbiology*
  • Lymphocyte Activation
  • Mice
  • Mice, Inbred C57BL
  • Mycobacterium bovis / immunology*
  • RNA, Messenger / analysis
  • T-Lymphocytes / immunology
  • Transforming Growth Factor beta / physiology*
  • Tuberculosis / immunology*

Substances

  • RNA, Messenger
  • Transforming Growth Factor beta
  • Interferon-gamma