Plasma cortisol levels in elderly female subjects with Alzheimer's disease: a cross-sectional and longitudinal study

Brain Res. 2000 Oct 27;881(2):241-3. doi: 10.1016/s0006-8993(00)02847-x.


We investigated the plasma cortisol levels at a fasting state in elderly female Alzheimer's disease (AD), vascular dementia (VD), and non-demented subjects (n=66, 28 and 21, respectively). Twenty-eight AD subjects were followed for 40 months. The plasma cortisol levels in AD and VD subjects were significantly higher than those of non-demented subjects at baseline. In AD subjects in relatively early stages of the disease [Mini-Mental State Examination (MMSE)], at baseline, high plasma cortisol led to rapid declines in MMSE scores over a 40-month period.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / blood*
  • Alzheimer Disease / psychology
  • Biomarkers / blood
  • Cross-Sectional Studies
  • Dementia, Vascular / blood*
  • Dementia, Vascular / psychology
  • Female
  • Humans
  • Hydrocortisone / blood*
  • Longitudinal Studies
  • Mental Status Schedule / statistics & numerical data*
  • Regression Analysis


  • Biomarkers
  • Hydrocortisone