Traumatic brain injury

Lancet. 2000 Sep 9;356(9233):923-9. doi: 10.1016/S0140-6736(00)02689-1.


The decrease in mortality and improved outcome for patients with severe traumatic brain injury over the past 25 years can be attributed to the approach of "squeezing oxygenated blood through a swollen brain". Quantification of cerebral perfusion by monitoring of intracranial pressure and treatment of cerebral hypoperfusion decrease secondary injury. Before the patient reaches hospital, an organised trauma system that allows rapid resuscitation and transport directly to an experienced trauma centre significantly lowers mortality and morbidity. Only the education of medical personnel and the institution of trauma hospital systems can achieve further improvements in outcome for patients with traumatic brain injuries.

Publication types

  • Review

MeSH terms

  • Blood Pressure / physiology
  • Brain Edema / physiopathology
  • Brain Injuries / complications
  • Brain Injuries / physiopathology
  • Brain Injuries / therapy*
  • Cerebrovascular Circulation / physiology
  • Emergency Medical Services
  • Humans
  • Intracranial Hypertension / therapy
  • Intracranial Hypotension / therapy
  • Intracranial Pressure / physiology
  • Prognosis
  • Resuscitation
  • Survival Rate
  • Trauma Centers
  • Treatment Outcome