Variance component methods for detecting complex trait loci

Adv Genet. 2001;42:151-81. doi: 10.1016/s0065-2660(01)42021-9.


Variance component-based linkage analysis has become a major statistical tool for the localization and evaluation of quantitative trait loci influencing complex phenotypes. The variance component approach has many benefits--it can, for example, be used to analyze large pedigrees, and it is able to accommodate multiple loci simultaneously in a true oligogenic model. Important biological phenomena such as genotype-environment interaction and epistasis are also examined easily in a variance component framework. In this chapter, we review the basic statistical features of variance component linkage analysis, with an emphasis on its power and robustness to distributional violations.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Analysis of Variance
  • Chromosome Mapping*
  • Genetic Linkage*
  • Genotype
  • Humans
  • Likelihood Functions
  • Models, Theoretical
  • Molecular Epidemiology
  • Multivariate Analysis
  • Nuclear Family
  • Phenotype
  • Quantitative Trait, Heritable*