[Effect of 7,8-benzoflavone on the incidence of skin tumors induced by polycyclic hydrocarbons]

Biull Eksp Biol Med. 1979 May;87(5):454-5.
[Article in Russian]

Abstract

Tumours were induced in CBA mice or (C57BL X CBA)F1 hybrids by the application of benz(a)pyrene (BP), 6-methylBP, 6-formylBP or 7,12-dimethylbenzanthracene (DMBA) to the skin. 7,8-benzoflavone (BF) used in combination with the mentioned agents decreased the carcinogenic action of methyl-substituted hydrocarbons--DMBA and 6-methylBP and had no effect on the carcinogenic action of BP and 6-formylBP. It is suggested that the inhibitory action of BF on carcinogenesis induced by methyl-substituted hydrocarbons was due to the inhibited oxidation of the methyl group.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene / antagonists & inhibitors*
  • Animals
  • Benz(a)Anthracenes / antagonists & inhibitors*
  • Benzoflavones / pharmacology*
  • Benzopyrenes*
  • Flavonoids / pharmacology*
  • Male
  • Mice
  • Neoplasms, Experimental / chemically induced
  • Neoplasms, Experimental / epidemiology
  • Skin Neoplasms / chemically induced
  • Skin Neoplasms / epidemiology*

Substances

  • Benz(a)Anthracenes
  • Benzoflavones
  • Benzopyrenes
  • Flavonoids
  • 9,10-Dimethyl-1,2-benzanthracene