Glycosyltransferase structure and mechanism

Curr Opin Struct Biol. 2000 Oct;10(5):510-7. doi: 10.1016/s0959-440x(00)00124-x.


The high-resolution X-ray crystal structures of a new form of bacteriophage T4 beta-glucosyltransferase, Escherichia coli MurG, Bacillus subtilis SpsA, bovine beta-1,4-galactosyltransferase 1 and rabbit N-acetylglucosaminyltransferase I have now been solved. These glycosyltransferase structures have provided the first detailed view of the structural basis of catalysis, as well as new insight into glycosyltransferase classification.

Publication types

  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Catalytic Domain
  • Crystallography, X-Ray
  • Glycosyltransferases / chemistry*
  • Glycosyltransferases / metabolism*
  • Structure-Activity Relationship


  • Glycosyltransferases