Recent advances in the study of the biosynthesis and functions of sulfated glycosaminoglycans

Curr Opin Struct Biol. 2000 Oct;10(5):518-27. doi: 10.1016/s0959-440x(00)00125-1.

Abstract

Recent cDNA cloning of the glycosyltransferases involved in the synthesis of the sulfated glycosaminoglycan sidechains of proteoglycans has provided important clues to answering long-standing questions concerning the mechanisms of both chain polymerization and the biosynthetic sorting of glucosaminoglycans (heparin/heparan sulfate) and galactosaminoglycans (chondroitin/dermatan sulfate). These biosynthetic mechanisms are crucial to the expression and regulation of the biological functions of glycosaminoglycans in development and pathophysiology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Glycosaminoglycans / biosynthesis*
  • Glycosaminoglycans / chemistry
  • Glycosaminoglycans / metabolism*
  • Proteins / metabolism
  • Sulfates / metabolism*

Substances

  • Glycosaminoglycans
  • Proteins
  • Sulfates