Chaperone-assisted pilus assembly and bacterial attachment

Curr Opin Struct Biol. 2000 Oct;10(5):548-56. doi: 10.1016/s0959-440x(00)00129-9.


Bacterial pili assembled by the chaperone-usher pathway can mediate microbial attachment, an early step in the establishment of an infection, by binding specifically to sugars present in host tissues. Recent work has begun to reveal the structural basis both of chaperone function in the biogenesis of these pili and of bacterial attachment.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adhesins, Bacterial / metabolism
  • Adhesins, Escherichia coli*
  • Bacterial Adhesion*
  • Fimbriae Proteins*
  • Fimbriae, Bacterial / metabolism*
  • Molecular Chaperones / chemistry
  • Molecular Chaperones / metabolism*
  • Organelles / metabolism
  • Protein Binding
  • Protein Conformation
  • Protein Folding


  • Adhesins, Bacterial
  • Adhesins, Escherichia coli
  • Molecular Chaperones
  • fimH protein, E coli
  • Fimbriae Proteins