The human ribosomal protein L6 gene in a critical region for Noonan syndrome

N Kenmochi; M Yoshihama; S Higa; T Tanaka

doi:10.1007/s100380070018

The human ribosomal protein L6 gene in a critical region for Noonan syndrome

J Hum Genet. 2000;45(5):290-3. doi: 10.1007/s100380070018.

Authors

N Kenmochi¹, M Yoshihama, S Higa, T Tanaka

Affiliation

¹ Department of Biochemistry, School of Medicine, University of the Ryukyus, Japan. kenmochi@med.u-ryukyu.ac.jp

PMID: 11043511
DOI: 10.1007/s100380070018

Abstract

We have determined the genomic structure of the human ribosomal protein L6 gene (RPL6) and assigned it to the interval containing the Noonan syndrome locus. RPL6 spans 4415bp and consists of seven exons and six introns. The first exon is only 19bp in length, containing a 5' non-coding region and a polypyrimidine tract. The second exon starts with the initiator ATG. Although the overall structure of the protein is highly conserved among mammalian species, there is significant variation in the N-terminal portion. We have refined the position of RPL6, using two different radiation hybrid panels. RPL6 was mapped to chromosome 12q24.1 between the markers D12S84 and D12S861, which is in the critical region for Noonan syndrome.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Chromosome Mapping
Chromosomes, Human, Pair 12*
Humans
Molecular Sequence Data
Noonan Syndrome / genetics*
Ribosomal Proteins / chemistry
Ribosomal Proteins / genetics*
Sequence Homology, Amino Acid

Substances

Ribosomal Proteins
ribosomal protein L6