Follicular stromal cells and lymphocyte homing to follicles

Immunol Rev. 2000 Aug;176:181-93. doi: 10.1034/j.1600-065x.2000.00618.x.

Abstract

Follicular dendritic cells (FDCs), the best defined stromal cell subset within lymphoid follicles, play a critical role in presenting intact antigen to B lymphocytes. The discovery that many follicular stromal cells make B-lymphocyte chemoattractant (BLC), a CXC chemokine that attracts CXCR5+ cells, provides a basis for understanding how motile B cells come into contact with stationary FDCs. Here we review our work on BLC and discuss properties of BLC-expressing follicular stromal cells. We also review the properties of primary follicle and germinal center FDCs and suggest a model of FDC development that incorporates information about BLC expression. Finally, we consider how antigen recognition causes T and B lymphocytes to undergo changes in chemokine responsiveness that may help direct their movements into, or out of, lymphoid follicles.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / cytology
  • B-Lymphocytes / immunology
  • Cell Movement
  • Chemokine CXCL13
  • Chemokines, CXC / metabolism
  • Dendritic Cells, Follicular / cytology*
  • Dendritic Cells, Follicular / immunology*
  • Humans
  • Lymphocytes / cytology*
  • Lymphocytes / immunology*
  • Lymphoid Tissue / cytology
  • Lymphoid Tissue / immunology
  • Lymphotoxin-alpha / metabolism
  • Mice
  • Models, Biological
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • CXCL13 protein, human
  • Chemokine CXCL13
  • Chemokines, CXC
  • Cxcl13 protein, mouse
  • Lymphotoxin-alpha
  • Tumor Necrosis Factor-alpha