An introduction to the changes in gene expression that occur after cerebral ischaemia

Br J Neurosurg. 2000 Aug;14(4):305-12. doi: 10.1080/026886900417261.


Ischaemia is the final common pathway of brain cell death following a variety of insults. We consider the effect of cerebral ischaemia on gene expression, concentrating on immediate early genes, those encoding heat shock proteins, growth factors, cytokines, adhesion molecules, nitric oxide synthase and proteins involved in programmed cell death. We conclude that the changes in gene expression resulting from ischaemia are important determinants of neuronal and glial survival. In the future it may become possible to manipulate gene expression to limit the extent of damage arising from cerebral ischaemia.

Publication types

  • Review

MeSH terms

  • Brain Ischemia / genetics*
  • Brain Ischemia / metabolism
  • Cell Death / genetics
  • Gene Expression Regulation*
  • Genes, Immediate-Early
  • Growth Substances / metabolism
  • Heat-Shock Proteins / metabolism
  • Humans
  • Nitric Oxide Synthase / metabolism


  • Growth Substances
  • Heat-Shock Proteins
  • Nitric Oxide Synthase