Heroin-induced spongiform leukoencephalopathy: value of diffusion MR imaging

J Comput Assist Tomogr. 2000 Sep-Oct;24(5):735-7. doi: 10.1097/00004728-200009000-00013.


The diffusion-weighted (DW) magnetic resonance (MR) imaging findings of a patient with subacute stage of heroin-induced vacuolating myelinopathy are reported. The diffuse decrease of apparent diffusion coefficient (ADC) of the white matter on DW imaging is attributed to restricted water diffusion, which is known to be caused by fluid entrapment within the myelin lamellae without demyelination.

Publication types

  • Case Reports

MeSH terms

  • Demyelinating Diseases / chemically induced*
  • Heroin / poisoning*
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged


  • Heroin