Abstract
Nondepleting anti-CD154 (CD40 ligand) mAbs have proven effective in inducing transplantation tolerance in rodents and primates. In the induction phase, anti-CD154 Ab therapy is known to enhance apoptosis of Ag reactive T cells. However, this may not be the sole explanation for tolerance, as we show in this study that tolerance is maintained through a dominant regulatory mechanism which, like tolerance induced with CD4 Abs, manifests as infectious tolerance. Therefore, tolerance induced with anti-CD154 Abs involves not only the deletion of potentially aggressive T cells, but also a contagious spread of tolerance to new cohorts of graft-reactive T cells as they arise.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adoptive Transfer
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Alemtuzumab
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Animals
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Antibodies, Monoclonal / administration & dosage
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Antibodies, Monoclonal / therapeutic use*
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Antibodies, Monoclonal, Humanized
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Antibodies, Neoplasm / administration & dosage
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CD40 Ligand / immunology*
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CD8-Positive T-Lymphocytes / immunology
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Injections, Intraperitoneal
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Injections, Intravenous
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Lymphocyte Depletion / methods
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Lymphocyte Transfusion
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Mice
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Mice, Inbred C57BL
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Mice, Inbred CBA
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Mice, Transgenic
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Skin Transplantation / immunology
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T-Lymphocytes / transplantation
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Thymectomy
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Transplantation Tolerance / genetics
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Transplantation Tolerance / immunology*
Substances
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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Antibodies, Neoplasm
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CD40 Ligand
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Alemtuzumab