Inhaled albuterol, but not intravenous lidocaine, protects against intubation-induced bronchoconstriction in asthma

Anesthesiology. 2000 Nov;93(5):1198-204. doi: 10.1097/00000542-200011000-00011.


Background: The ability of intravenous lidocaine to prevent intubation-induced bronchospasm is unclear. The authors performed a prospective, randomized, double-blind, placebo-controlled trial to test the ability of intravenous lidocaine and inhaled albuterol to attenuate airway reactivity after tracheal intubation in asthmatic patients undergoing general anesthesia.

Methods: Sixty patients were randomized to receive either 1.5 mg/kg intravenous lidocaine or saline, 3 min before tracheal intubation. An additional 50 patients were randomized to receive 4 puffs of inhaled albuterol or placebo 15-20 min before tracheal intubation. Anesthesia was induced with propofol. Immediately after intubation and at 5-min intervals, transpulmonary pressure and airflow were recorded, and lower pulmonary resistance (RL) was calculated. Isoflurane was administered after the initial two measurements to assess reversibility of bronchoconstriction. A bronchoconstrictor response to intubation was defined as RL greater than or equal to 5 cm H2O. l-1. s-1 in the first two measurements after intubation and RL subsequently decreasing by 50% or more after isoflurane.

Results: The lidocaine and placebo groups were not different in the peak RL before administration of isoflurane (8.2 cm H2O. l-1. s-1 vs. 7.6 cm H2O. l-1. s-1) or frequency of airway response to intubation (lidocaine 6 of 30 vs. placebo 5 of 27). In contrast, the albuterol group had lower peak RL (5.3 cm H2O. l-1. s-1 vs. 8.9 cm H2O. l-1. s-1; P < 0.05) and a lower frequency of airway response (1 of 25 vs. 8 of 23; P < 0.05) than the placebo group.

Conclusions: Inhaled albuterol blunted airway response to tracheal intubation in asthmatic patients, whereas intravenous lidocaine did not.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Inhalation
  • Adult
  • Albuterol / administration & dosage*
  • Anesthesia, Inhalation
  • Anesthetics, Inhalation / administration & dosage
  • Anesthetics, Local / administration & dosage*
  • Asthma / complications*
  • Bronchial Spasm / etiology
  • Bronchial Spasm / prevention & control*
  • Bronchodilator Agents / administration & dosage*
  • Double-Blind Method
  • Female
  • Humans
  • Injections, Intravenous
  • Intubation, Intratracheal / adverse effects*
  • Isoflurane / administration & dosage
  • Lidocaine / administration & dosage*
  • Male
  • Placebos
  • Prospective Studies


  • Anesthetics, Inhalation
  • Anesthetics, Local
  • Bronchodilator Agents
  • Placebos
  • Lidocaine
  • Isoflurane
  • Albuterol