Cellular basis of tolerance in neonatally induced mouse chimeras

J Exp Med. 1975 Nov 1;142(5):1312-5. doi: 10.1084/jem.142.5.1312.


In mice, thymectomized as young adults, neonatally induced tolerance persists in the putative absence of cell chimerism. The finding provides evidence that a selective deficiency of specific clones of lymphocytes exists in transplantation tolerance when induced under the conditions of these experiments.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Animals, Newborn / immunology*
  • Chimera
  • Female
  • Immune Tolerance*
  • Immunity, Cellular*
  • Male
  • Mice
  • Mice, Inbred Strains
  • Skin Transplantation
  • T-Lymphocytes / immunology
  • Thymectomy
  • Thymus Gland / immunology
  • Transplantation, Homologous