One-year follow-up of disulfiram and psychotherapy for cocaine-alcohol users: sustained effects of treatment

Addiction. 2000 Sep;95(9):1335-49. doi: 10.1046/j.1360-0443.2000.95913355.x.


Aim: To evaluate outcomes 1 year after cessation of treatment for cocaine- and alcohol-dependent individuals.

Design: Randomized controlled trial.

Setting: Urban substance abuse treatment center.

Participants: Ninety-six of 122 subjects randomized to treatment.

Interventions: One of five treatments delivered over 12 weeks. Cognitive-behavioral treatment (CBT) plus disulfiram; Twelve-Step facilitation (TSF) plus disulfiram; clinical management (CM) plus disulfiram; CBT without disulfiram; TSF without disulfiram.

Measurements: Percentage of days of cocaine and alcohol use during follow-up, verified by urine toxicology screens and breathalyzer tests.

Results: First, as a group, participants reported significant decreases in frequency of cocaine, but not alcohol, use after the end of treatment. Secondly, the main effects of disulfiram on cocaine and alcohol use were sustained during follow-up. Finally, initiation of abstinence for even brief periods of time within treatment was associated with significantly better outcome during follow-up.

Conclusions: These findings support the efficacy of disulfiram with this challenging population and suggest that comparatively brief treatments that facilitate the initiation of abstinence may have long-term benefits.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Alcohol Deterrents / therapeutic use*
  • Alcoholism / complications
  • Alcoholism / therapy*
  • Cocaine-Related Disorders / complications
  • Cocaine-Related Disorders / therapy*
  • Cognitive Behavioral Therapy
  • Combined Modality Therapy
  • Disulfiram / therapeutic use*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Psychotherapy / methods*
  • Temperance
  • Treatment Outcome


  • Alcohol Deterrents
  • Disulfiram