The mechanism of phospholipase C-gamma1 regulation

Exp Mol Med. 2000 Sep 30;32(3):101-9. doi: 10.1038/emm.2000.18.


Phospholipase C (PLC)1 hydrolyzes phosphatidylinositol 4,5-bisphosphate to generate the second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces a transient increase in intracellular free Ca2+, while DAG directly activates protein kinase C. Upon stimulation of cells with growth factors, PLC-gamma1 is activated upon their association with and phosphorylation by receptor and non-receptor tyrosine kinases. In this review, we will focus on the activation mechanism and regulatory function of PLC-gamma1.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Division
  • Enzyme Activation
  • Isoenzymes / metabolism*
  • Phospholipase C gamma
  • Second Messenger Systems
  • T-Lymphocytes
  • Type C Phospholipases / metabolism*


  • Isoenzymes
  • Type C Phospholipases
  • Phospholipase C gamma