Effect of age on lipid peroxides, lipofuscin and ascorbic acid contents of the lungs of male garden lizard

Comp Biochem Physiol C Toxicol Pharmacol. 2000 Jul;126(3):293-8. doi: 10.1016/s0742-8413(00)00122-5.


Oxidative damage was assessed through the estimation of lipid peroxides (LP) in the lungs of an ageing short-lived species of reptile, Calotes versicolor, commonly known as the garden lizard. Attempts were also made to trace its relationship with the age pigment, lipofuscin and the antioxidant ascorbic acid. While LP increased with advancing age the contents of both lipofuscin and ascorbic acid did not show appreciable change during maturation ( < 1-1 year old) but declined during senescence phase (1 to 2-4 year old). While the pattern of age associated changes in LP and ascorbic acid indicate similarity with the pattern observed in most of the mammals, the reduction of lipofuscin in older lizards is a significant departure from the common trend.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / metabolism*
  • Animals
  • Ascorbic Acid / metabolism*
  • Lipid Peroxides / metabolism*
  • Lipofuscin / metabolism*
  • Lizards
  • Lung / metabolism*
  • Male


  • Lipid Peroxides
  • Lipofuscin
  • Ascorbic Acid