The Biochemistry of Apoptosis

Nature. 2000 Oct 12;407(6805):770-6. doi: 10.1038/35037710.

Abstract

Apoptosis--the regulated destruction of a cell--is a complicated process. The decision to die cannot be taken lightly, and the activity of many genes influence a cell's likelihood of activating its self-destruction programme. Once the decision is taken, proper execution of the apoptotic programme requires the coordinated activation and execution of multiple subprogrammes. Here I review the basic components of the death machinery, describe how they interact to regulate apoptosis in a coordinated manner, and discuss the main pathways that are used to activate cell death.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Caspases / metabolism
  • Humans
  • Mitochondria / physiology

Substances

  • Caspases