BRCA1: exploring the links to transcription

Trends Biochem Sci. 2000 Oct;25(10):469-74. doi: 10.1016/s0968-0004(00)01632-7.


Progress on determining the function of the breast and ovarian cancer susceptibility gene BRCA1 suggests it might be involved in two fundamental cellular processes: DNA repair and transcriptional regulation. Recent developments indicate that BRCA1 is a multifunctional protein, and disruption of its transcriptional activity could be crucial for tumor development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • BRCA1 Protein / genetics*
  • BRCA1 Protein / metabolism*
  • DNA Repair
  • Humans
  • RNA Polymerase II / metabolism*
  • Transcription, Genetic*
  • Transcriptional Activation


  • BRCA1 Protein
  • RNA Polymerase II