Mitochondria, oxygen free radicals, disease and ageing

S Raha; B H Robinson

doi:10.1016/s0968-0004(00)01674-1

Mitochondria, oxygen free radicals, disease and ageing

Trends Biochem Sci. 2000 Oct;25(10):502-8. doi: 10.1016/s0968-0004(00)01674-1.

Authors

S Raha¹, B H Robinson

Affiliation

¹ Metabolism Research Programme, The Research Institute, The Hospital for Sick Children, 555 University Ave., M5G 1X8, Toronto, Canada.

PMID: 11050436
DOI: 10.1016/s0968-0004(00)01674-1

Abstract

Superoxide is generated by the mitochondrial respiratory chain. The transformation of this superoxide into hydrogen peroxide and, under certain conditions, then into hydroxyl radicals is important in diseases where respiratory chain function is abnormal or where superoxide dismutase function is altered, as in amyotrophic lateral sclerosis. In addition, these reactive oxygen species can influence the ageing process through mechanisms involving mutagenesis of mtDNA or increased rates of shortening of telomeric DNA.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aging / physiology*
Disease
Electron Transport Complex I
Electron Transport Complex III / metabolism*
Humans
Metabolism, Inborn Errors / metabolism
Mitochondria / metabolism*
NADH, NADPH Oxidoreductases / deficiency
NADH, NADPH Oxidoreductases / metabolism*
Reactive Oxygen Species / metabolism*
Superoxide Dismutase / genetics
Superoxide Dismutase / metabolism
Superoxides / metabolism

Substances

Reactive Oxygen Species
Superoxides
Superoxide Dismutase
NADH, NADPH Oxidoreductases
Electron Transport Complex I
Electron Transport Complex III