In general practice, as in all branches of medicine, doctors are encouraged to ensure their decisions reflect research findings, and are 'evidence-based'. This depends upon general practitioners (GPs) questioning their practice, finding 'evidence-based' answers, and changing their practice where necessary. Questioning behaviour is therefore fundamental to this process. Research into the questioning behaviour and information needs of GPs is difficult and it is unknown whether better access to information necessarily results in behavioural change or better health outcomes. This paper summarises research on doctors' questioning behaviour, factors influencing their likelihood of finding answers, and discusses some of the obstacles they face in implementing change. Finally, we introduce the concept of a 'clinical informaticist', whose role is to provide evidence-based answers to specific questions raised by GPs. This service may facilitate learning and increase uptake of research findings.