Levodopa motor complications in Parkinson's disease

Trends Neurosci. 2000 Oct;23(10 Suppl):S2-7. doi: 10.1016/s1471-1931(00)00031-8.


Parkinson's disease (PD) is an age-related neurodegenerative disorder with an average onset age of 60 years. In the United States, approximately one million persons suffer from PD, and there are 60,000 newly diagnosed cases every year. The estimated cost of PD to society is $27 billion per year. Based on United States Census Bureau projections, it is estimated that the frequency of PD will increase fourfold by the year 2040, making it an even larger burden on patients, their families and society.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Age of Onset
  • Antiparkinson Agents / adverse effects*
  • Brain / metabolism*
  • Cost of Illness
  • Dyskinesia, Drug-Induced* / etiology
  • Dyskinesia, Drug-Induced* / prevention & control
  • Humans
  • Incidence
  • Levodopa / adverse effects*
  • Male
  • Parkinson Disease / drug therapy*
  • Parkinson Disease / metabolism
  • Receptors, Dopamine / drug effects*
  • Receptors, Dopamine / metabolism
  • Severity of Illness Index


  • Antiparkinson Agents
  • Receptors, Dopamine
  • Levodopa