Effect of sleep deprivation on overall 24 h growth-hormone secretion

Lancet. 2000 Oct 21;356(9239):1408. doi: 10.1016/S0140-6736(00)02847-6.


After sleep deprivation, the blunting of the normal sleep-related growth-hormone (GH) pulse is compensated during the day. Consequently, the amount of GH secreted during a 24 h period is similar whether or not a person has slept during the night. These results argue against the belief that sleep disorders in children can inhibit growth through a daily GH deficit.

Publication types

  • Letter

MeSH terms

  • Adult
  • Human Growth Hormone / blood
  • Human Growth Hormone / metabolism*
  • Humans
  • Sleep
  • Sleep Deprivation / metabolism*


  • Human Growth Hormone