Diversity and dynamics of dendritic signaling

Science. 2000 Oct 27;290(5492):739-44. doi: 10.1126/science.290.5492.739.


Communication between neurons in the brain occurs primarily through synapses made onto elaborate treelike structures called dendrites. New electrical and optical recording techniques have led to tremendous advances in our understanding of how dendrites contribute to neuronal computation in the mammalian brain. The varied morphology and electrical and chemical properties of dendrites enable a spectrum of local and long-range signaling, defining the input-output relationship of neurons and the rules for induction of synaptic plasticity. In this way, diversity in dendritic signaling allows individual neurons to carry out specialized functions within their respective networks.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Action Potentials
  • Animals
  • Brain / physiology
  • Calcium Signaling
  • Dendrites / physiology*
  • Electrophysiology
  • Humans
  • Ion Channel Gating
  • Ion Channels / physiology
  • Neuronal Plasticity*
  • Neurons / physiology
  • Neurotransmitter Agents / physiology
  • Protein Biosynthesis
  • Signal Transduction*
  • Synapses / physiology*
  • Synaptic Transmission*


  • Ion Channels
  • Neurotransmitter Agents