Motor cortex disinhibition of the unaffected hemisphere after acute stroke

Muscle Nerve. 2000 Nov;23(11):1761-3. doi: 10.1002/1097-4598(200011)23:11<1761::aid-mus14>;2-m.


We studied motor cortex excitability in the nonlesioned hemisphere of patients with a large cortical infarction. Patients with a severe hemiparesis due to a stroke were compared with age-matched, healthy controls. Paired transcranial magnetic stimuli were applied over the unaffected hemisphere to investigate intracortical inhibition and facilitation. In the patient group, intracortical inhibition was reduced. We suggest that this disinhibition is due to an impairment of transcallosal fibers and may affect recovery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Aged
  • Cerebral Infarction / diagnosis
  • Cerebral Infarction / physiopathology
  • Dominance, Cerebral / physiology
  • Electric Stimulation
  • Female
  • Humans
  • Magnetics
  • Male
  • Middle Aged
  • Motor Cortex / blood supply
  • Motor Cortex / physiopathology*
  • Neural Inhibition / physiology*
  • Paresis / diagnosis
  • Paresis / physiopathology
  • Recovery of Function / physiology
  • Stroke / diagnosis
  • Stroke / physiopathology*