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. 2000 Nov;14(7):495-500.
doi: 10.1002/1099-1573(200011)14:7<495::aid-ptr650>3.0.co;2-8.

In Vitro and in Vivo Activity of Eugenol on Human Herpesvirus

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In Vitro and in Vivo Activity of Eugenol on Human Herpesvirus

F Benencia et al. Phytother Res. .

Abstract

Eugenol (4-allyl-1-hydroxy-2-methoxybenzene) was tested for antiviral activity against HSV-1 and HSV-2 viruses. In vitro, it was found that the replication of these viruses was inhibited in the presence of this compound. Inhibitory concentration 50% values for the anti-HSV effects of eugenol were 25.6 microg/mL and 16.2 microg/mL for HSV-1 and HSV-2 respectively, 250 microg/mL being the maximum dose at which cytotoxicity was tested. Eugenol was virucidal and showed no cytotoxicity at the concentrations tested. Eugenol-acyclovir combinations synergistically inhibited herpesvirus replication in vitro. Topical application of eugenol delayed the development of herpesvirus induced keratitis in the mouse model.

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