Implementing a unified approach to family-based tests of association

Genet Epidemiol. 2000;19 Suppl 1:S36-42. doi: 10.1002/1098-2272(2000)19:1+<::AID-GEPI6>3.0.CO;2-M.

Abstract

We describe a broad class of family-based association tests that are adjusted for admixture; use either dichotomous or measured phenotypes; accommodate phenotype-unknown subjects; use nuclear families, sibships or a combination of the two, permit multiple nuclear families from a single pedigree; incorporate di- or multi-allelic marker data; allow additive, dominant or recessive models; and permit adjustment for covariates and gene-by-environment interactions. The test statistic is basically the covariance between a user-specified function of the genotype and a user-specified function of the trait. The distribution of the statistic is computed using the appropriate conditional distribution of offspring genotypes that adjusts for admixture.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Genotype
  • Humans
  • Models, Genetic*
  • Phenotype
  • Software
  • Statistics as Topic*