Safety assessment of rice genetically modified with soybean glycinin by feeding studies on rats

Biosci Biotechnol Biochem. 2000 Sep;64(9):1881-6. doi: 10.1271/bbb.64.1881.


Feeding studies on rice genetically modified with soybean glycinin were performed on rats for four weeks. The rats were divided into three groups, each being fed on (I) only a commercial diet, (II) this diet plus control rice and (III) this diet plus rice genetically modified with glycinin. The rats were fed with 10 g/kg-weight of rice every day by oral administration. During the test period, the rats in every group grew well without marked differences in appearance, food intake, body weight, or cumulative body weight gain. There were also no significant differences in the blood count, blood composition or internal organ weights among the rats. Necropsy at the end of the experiment indicated neither pathological symptoms nor histopathological abnormalities in the liver and kidney. Judging from these results, the rice genetically modified with glycinin is considered to have been essentially the same in nutritional and biochemical characteristics as the control rice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animal Feed*
  • Animals
  • Body Weight
  • Globulins / genetics*
  • Hematocrit
  • Leukocyte Count
  • Male
  • Organ Size
  • Oryza / genetics*
  • Oryza / standards*
  • Plants, Genetically Modified*
  • Rats
  • Rats, Inbred Strains
  • Safety
  • Soybean Proteins
  • Soybeans / genetics*
  • Weight Gain


  • Globulins
  • Soybean Proteins
  • glycinin