Gene aberrations in childhood brain tumors

Folia Biol (Praha). 2000;46(5):187-90.


We present the results of the examination of prognostic markers in 40 children suffering from brain tumors. Prognostic markers such as amplification of the N-myc and c-myc, deletion of the 17p, and DNA ploidy are indispensable factors for the determination of diagnosis. An increased number of c-myc gene copies was found in malignant brain tumors, especially embryonal, more often than reported in the literature. N-myc amplification occurs in our group seldom, but it seems to be a sign of worse prognosis in glial and embryonal brain tumors. DNA aneuploidy was not found very frequently, but in high-grade tumors only.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Aneuploidy*
  • Brain Neoplasms / classification
  • Brain Neoplasms / genetics*
  • Cerebellar Neoplasms / genetics
  • Child
  • Child, Preschool
  • Chromosome Aberrations*
  • Chromosome Deletion
  • Chromosomes, Human, Pair 17
  • Female
  • Gene Amplification
  • Gene Duplication
  • Genes, myc
  • Glioma / genetics
  • Humans
  • In Situ Hybridization, Fluorescence
  • Infant
  • Male
  • Medulloblastoma / genetics
  • Neuroectodermal Tumors, Primitive / genetics
  • Ploidies