Immune regulation by CD40-CD40-l interactions - 2; Y2K update

Front Biosci. 2000 Nov 1;5:D880-693. doi: 10.2741/kooten.

Abstract

CD40 is a cell surface receptor, which belongs to the TNF-R family, and which was first identified and functionally characterized on B lymphocytes. However, in recent years it has become clear that CD40 is expressed much broader, including expression on monocytes, dendritic cells, endothelial cells and epithelial cells. Therefore it is now thought that CD40 plays a more general role in immune regulation. The present paper reviews recent developments in this field of research, with main emphasis on CD40 signal transduction and on in vivo functions of CD40/CD40-L interactions.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibody Formation / immunology
  • Autoimmunity / immunology
  • CD40 Antigens / immunology
  • CD40 Antigens / metabolism*
  • CD40 Ligand / immunology
  • CD40 Ligand / metabolism*
  • Dendritic Cells / immunology
  • Dendritic Cells / metabolism
  • Epithelial Cells / immunology
  • Epithelial Cells / metabolism
  • Fibroblasts / immunology
  • Herpesvirus 4, Human / immunology
  • Humans
  • Immune System / metabolism*
  • Inflammation / metabolism
  • Lymphocytes / immunology
  • Lymphocytes / metabolism
  • Mice
  • Monocytes / immunology
  • Monocytes / metabolism
  • Proteins / genetics
  • Proteins / metabolism
  • Signal Transduction / immunology*
  • TNF Receptor-Associated Factor 1
  • TNF Receptor-Associated Factor 2
  • TNF Receptor-Associated Factor 3
  • TNF Receptor-Associated Factor 5
  • TNF Receptor-Associated Factor 6
  • Transplantation Tolerance / immunology

Substances

  • CD40 Antigens
  • Proteins
  • TNF Receptor-Associated Factor 1
  • TNF Receptor-Associated Factor 2
  • TNF Receptor-Associated Factor 3
  • TNF Receptor-Associated Factor 5
  • TNF Receptor-Associated Factor 6
  • CD40 Ligand