Decreased inhibition of platelet aggregation by PGE1 in children with cystic fibrosis and their parents

Prostaglandins. 1975 Oct;10(4):617-21. doi: 10.1016/s0090-6980(75)80008-6.

Abstract

PGE1 inhibited ADP-induced platelet aggregation in children with cystic fibrosis and their parents to a much lesser extent than in normal controls. We suggest that this may be a reliable test for heterozygote carriers of cystic fibrosis.

Publication types

  • Clinical Trial

MeSH terms

  • Adenosine Diphosphate / pharmacology
  • Adult
  • Carrier State / blood
  • Child
  • Clinical Trials as Topic
  • Cystic Fibrosis / blood*
  • Cystic Fibrosis / diagnosis
  • Depression, Chemical
  • Humans
  • Platelet Aggregation / drug effects*
  • Prostaglandins E / pharmacology*

Substances

  • Prostaglandins E
  • Adenosine Diphosphate