Thrombolytic therapy in patients with portal vein thrombosis: case report and review of the literature

Eur J Gastroenterol Hepatol. 2000 Oct;12(10):1141-5. doi: 10.1097/00042737-200012100-00012.


A 29-year-old male patient with Crohn's disease of the terminal ileum and previous abdominal surgery was admitted because of severe abdominal pain and signs of bacterial sepsis. The diagnosis of portal vein thrombosis and multiple liver abscesses due to Streptococcus intermedius septicaemia was made and antibiotic therapy was instituted immediately. As high-dose heparin therapy was ineffective, urokinase was administered intravenously over a total of 7 days. Within 2 days, the patient's symptoms completely subsided. Colour duplex ultrasonography revealed complete recanalization of the main stem of the portal vein; the right branch of the portal vein, however, remained occluded. Other case reports on thrombolytic therapy in patients with portal vein thrombosis are reviewed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Budd-Chiari Syndrome / drug therapy*
  • Budd-Chiari Syndrome / etiology
  • Crohn Disease / complications
  • Fibrinolytic Agents / therapeutic use
  • Heparin / therapeutic use
  • Humans
  • Male
  • Plasminogen Activators / therapeutic use*
  • Portal Vein / pathology*
  • Streptococcal Infections / complications
  • Streptococcus / isolation & purification
  • Thrombolytic Therapy / methods*
  • Ultrasonics
  • Urokinase-Type Plasminogen Activator / therapeutic use*


  • Fibrinolytic Agents
  • Heparin
  • Plasminogen Activators
  • Urokinase-Type Plasminogen Activator