Conjugated linoleic acid: implications for human health

Pharmacol Res. 2000 Dec;42(6):503-10. doi: 10.1006/phrs.2000.0735.


Conjugated linoleic acid (CLA) is being sold as a panacea that has the capability of reducing or eliminating cancer, preventing heart disease, improving immune function, and altering body composition to treat obesity or build lean body mass. Unfortunately, there has been very little published human research on CLA. This review will examine the literature on CLA and discuss the animal research on which the above claims are made. The limited human studies will be presented with an evaluation of the potential uses of CLA for human health and disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adjuvants, Immunologic / pharmacology*
  • Animals
  • Anticarcinogenic Agents / pharmacology*
  • Arteriosclerosis / drug therapy*
  • Body Composition / drug effects*
  • Humans
  • Linoleic Acid / pharmacology*


  • Adjuvants, Immunologic
  • Anticarcinogenic Agents
  • Linoleic Acid