Frontiers in chemical genetics

Trends Biotechnol. 2000 Nov;18(11):449-55. doi: 10.1016/s0167-7799(00)01499-2.


New methods enable the identification of compounds that both induce a specific cellular state and lead to identification of proteins that regulate that state. Together, developments in three critical areas: chemical diversity, phenotype-based screening and target identification, enable the systematic application of this chemical genetic approach to almost any biological problem or disease process.

Publication types

  • Review

MeSH terms

  • Animals
  • Biopolymers
  • Biotechnology
  • Chemistry, Organic
  • Genetic Markers
  • Genetic Testing
  • Humans
  • Models, Genetic
  • Molecular Biology / trends*
  • Organic Chemistry Phenomena
  • Phenotype


  • Biopolymers
  • Genetic Markers