Arterial dissections of penetrating cerebral arteries causing hypertension-induced cerebral hemorrhage

J Neurosurg. 2000 Nov;93(5):859-62. doi: 10.3171/jns.2000.93.5.0859.

Abstract

Object: For the past 130 years, it has been believed that hypertension-induced cerebral hemorrhages are the result of ruptures of microaneurysms or ruptures of arteries that have degenerative changes. The majority of previous investigations have focused on autopsied brain. In this study, the authors attempted to verify the cause of hypertension-induced cerebral hemorrhage by using surgical specimens of the penetrating arteries responsible for the hemorrhages.

Methods: Between 1997 and 1999, the authors performed pathological studies in surgical specimens of lenticulostriate arteries that had been confirmed during microsurgery to be the cause of hypertension-induced hemorrhage of the putamen. Nineteen lenticulostriate arteries were collected from 12 patients. Fifteen of these arteries were verified as the pathological causes of hemorrhage. They included six arterial dissections, six arterial ruptures with substantial degenerative changes, and three arterial ruptures with few degenerative changes. The pathological findings in the lenticulostriate artery dissections were similar to those of typical arterial dissections in major cerebral arteries.

Conclusions: To the best of the authors' knowledge, arterial dissections of lenticulostriate arteries have not been identified as a cause of hypertension-induced cerebral hemorrhages. When penetrating arteries are included as causative vessels, cerebral arterial dissections may be much more common than previously thought.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aneurysm, Dissecting / complications
  • Aneurysm, Dissecting / pathology*
  • Aneurysm, Ruptured / complications
  • Aneurysm, Ruptured / pathology*
  • Anterior Cerebral Artery / pathology*
  • Basal Ganglia Cerebrovascular Disease / etiology
  • Basal Ganglia Cerebrovascular Disease / pathology*
  • Humans
  • Hypertension / complications
  • Hypertension / pathology
  • Intracranial Aneurysm / complications
  • Intracranial Aneurysm / pathology
  • Intracranial Hemorrhage, Hypertensive / etiology
  • Intracranial Hemorrhage, Hypertensive / pathology*
  • Middle Aged
  • Tunica Intima / pathology