Erectogenic effect of the selective phosphodiesterase type 5 inhibitor, DA-8159

Arch Pharm Res. 2000 Oct;23(5):471-6. doi: 10.1007/BF02976575.


DA-8159, a new phosphodiesterase 5 inhibitor, was assessed for its erectogenic potential by a penile erection test in rats, the relaxation of isolated rabbit corpus cavernosum (CC), and estimation of the intracavernous pressure (ICP) in the anesthetized dog. Oral administration of DA-8159 (0.3 to 1 mg/kg) increased the number of erections in rats with increasing dosage, with the highest penile erection index at 10 mg/kg. DA-8159 induced the relaxation of phenylephrine (PHE)-induced contractions in the rabbit CC and decreased the IC50 of the nitric oxide donor sodium nitroprusside (SNP) in a dose-dependent fashion. In pentobarbital-anesthetized dogs, the intravenous administration of DA-8159 (1 approximately 300 g/kg) potentiated the increase in ICP induced by the intracavernosal SNP in a dose-related manner. These findings suggest that DA-8159 has significant therapeutic potential in the treatment of erectile dysfunction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dogs
  • Dose-Response Relationship, Drug
  • In Vitro Techniques
  • Male
  • Nitroprusside / pharmacology
  • Penile Erection / drug effects*
  • Phosphodiesterase Inhibitors / pharmacology*
  • Pyrimidines*
  • Rabbits
  • Rats
  • Rats, Sprague-Dawley
  • Sulfonamides


  • Phosphodiesterase Inhibitors
  • Pyrimidines
  • Sulfonamides
  • Nitroprusside
  • udenafil