Peripheral axotomy increases cholecystokinin release in the rat anterior cingulate cortex

Neuroreport. 2000 Oct 20;11(15):3345-8. doi: 10.1097/00001756-200010200-00016.


The anterior cingulate cortex (ACC) is a limbic region with a high density of cholecystokinin (CCK) immunoreactivity, that has been suggested to be of importance for the affective and emotional component of pain. In the present microdialysis study, performed in the awake rat, we demonstrate a bilateral 4- to 6-fold increase of the potassium-induced release of CCK-like immunoreactivity (CCK-LI) in the ACC 2-3 weeks after a unilateral transection of the sciatic nerve (axotomy), an animal model of phantom limb or deafferentiation pain. Considering the implication of CCK in pain modulation and anxiety, we suggest that an altered activity of CCK containing neurons in the ACC may be of importance for the affective component of certain pain conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Axotomy*
  • Cholecystokinin / metabolism*
  • Gyrus Cinguli / drug effects
  • Gyrus Cinguli / metabolism*
  • Male
  • Microdialysis
  • Potassium / pharmacology
  • Radioimmunoassay
  • Rats
  • Rats, Sprague-Dawley
  • Sciatic Nerve / physiology*


  • Cholecystokinin
  • Potassium