Ziprasidone: comprehensive overview and clinical use of a novel antipsychotic

Expert Opin Investig Drugs. 2000 Apr;9(4):819-28. doi: 10.1517/13543784.9.4.819.


Ziprasidone (5-[2-(4-(1,2,-benzisothiazol-3-yl) piperazin-l-yl] ethyl]-6 -chloro indolin-2-one hydrochloride hydrate) is a novel antipsychotic with a pattern of receptor occupancy and preclinical attributes predictive of broad therapeutic efficacy and a favourable tolerability profile in the treatment of psychotic illness. Clinical trials indicate that ziprasidone is effective against positive, negative and affective symptoms in schizophrenia and schizoaffective disorder with minimal motor, cognitive, weight gain, prolactin related, or anticholinergic side effects. In addition, an im. formulation appears to be rapidly effective with significantly less motor side effect liability than haloperidol.

Publication types

  • Review

MeSH terms

  • Animals
  • Antipsychotic Agents / pharmacokinetics
  • Antipsychotic Agents / therapeutic use*
  • Clinical Trials as Topic
  • Humans
  • Piperazines / pharmacokinetics
  • Piperazines / therapeutic use*
  • Psychotic Disorders / drug therapy*
  • Schizophrenia / drug therapy*
  • Schizophrenic Psychology
  • Serotonin Antagonists / pharmacokinetics
  • Serotonin Antagonists / therapeutic use
  • Thiazoles / pharmacokinetics
  • Thiazoles / therapeutic use*


  • Antipsychotic Agents
  • Piperazines
  • Serotonin Antagonists
  • Thiazoles
  • ziprasidone