Inhibitors of aminoacyl-tRNA synthetases as novel anti-infectives

Expert Opin Investig Drugs. 2000 Aug;9(8):1767-75. doi: 10.1517/13543784.9.8.1767.

Abstract

Resistance to existing antibiotics has emerged as a major problem in healthcare. Novel antibiotics for which bacteria have not yet acquired resistance need to be developed to combat drug-resistant pathogens. Aminoacyl-tRNA synthetases are leading targets for novel anti-infectives. The validation of aminoacyl-tRNA synthetases as drug targets for anti-infectives has been established in an animal system. Using several conceptually distinct approaches, new inhibitors of synthetases have been developed as drug prototypes.

Publication types

  • Review

MeSH terms

  • Amino Acyl-tRNA Synthetases / antagonists & inhibitors*
  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Enzyme Inhibitors / pharmacology*
  • Humans

Substances

  • Anti-Bacterial Agents
  • Enzyme Inhibitors
  • Amino Acyl-tRNA Synthetases