Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK1195

Neurology. 2000 Oct 10;55(7):1052-4. doi: 10.1212/wnl.55.7.1052.

Abstract

Using quantitative PET, the authors studied the binding of [11C]PK11195, a marker of activated microglia, in the thalamus of patients with chronic middle cerebral artery infarcts. All patients showed increased [11C]PK11195 binding in the ipsilateral thalamus, indicating the activation of microglia in degenerating projection areas remote from the primary lesion. A persistent increase in [11C]PK11195 binding suggests active, long-term thalamic microstructural changes after corticothalamic connection damage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Brain Ischemia / diagnostic imaging*
  • Brain Ischemia / pathology*
  • Carbon Radioisotopes*
  • Female
  • Humans
  • Isoquinolines*
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Stroke / diagnostic imaging*
  • Stroke / pathology*
  • Thalamic Nuclei / diagnostic imaging*
  • Thalamic Nuclei / pathology*
  • Tomography, Emission-Computed

Substances

  • Carbon Radioisotopes
  • Isoquinolines
  • PK 11195