Vascular lesions involving osseous structures are relatively common neoplasms. We will review the appearance of many musculoskeletal angiomatous lesions using the multimodality approach. Lesions to be discussed include osseous hemangioma, glomus tumor, angiomatosis and associated syndromes (Osler-Weber-Rendu, Klippel-Trenaunay-Weber, and Kasabach-Merritt), Gorham, tumor-induced osteomalacia, and aggressive vascular neoplasms (hemangioendothelioma, hemangiopericytoma, and angiosarcoma).