Comparative activities of polycationic peptides and clinically used antimicrobial agents against multidrug-resistant nosocomial isolates of Acinetobacter baumannii

J Antimicrob Chemother. 2000 Nov;46(5):807-10. doi: 10.1093/jac/46.5.807.

Abstract

The in vitro activity of buforin II, cecropin P1, indolicidin, magainin II and ranalexin, alone and in combination with eight clinically used antimicrobial agents was investigated against 12 multidrug-resistant strains of Acinetobacter baumannii isolated from immunocompromised patients. Antimicrobial activities were measured by MIC, MBC and viable count. The peptides had a varied range of inhibitory values: overall, the organisms were more susceptible to buforin II (MIC range 0.25-16 mg/L), cecropin P1 (0.50-32 mg/L) and magainin II (0.50-16 mg/L). Synergy occurred when magainin II was combined with beta-lactam antibiotics.

MeSH terms

  • Acinetobacter / drug effects*
  • Acinetobacter / immunology
  • Anti-Bacterial Agents / pharmacology*
  • Antimicrobial Cationic Peptides / pharmacology*
  • Cross Infection* / immunology
  • Drug Resistance, Multiple* / immunology
  • Drug Therapy, Combination / pharmacology*
  • Humans
  • Microbial Sensitivity Tests / methods

Substances

  • Anti-Bacterial Agents
  • Antimicrobial Cationic Peptides