Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle

Curr Opin Cell Biol. 2000 Dec;12(6):676-84. doi: 10.1016/s0955-0674(00)00151-4.


Cyclin-dependent kinases are the key regulators of cell-cycle transitions. In mammalian cells, Cdk2, Cdk4, Cdk6 and associated cyclins control the G(1) to S phase transition. Because proper regulation of this transition is critical for an organism's survival, these protein kinases are exquisitely regulated at different mechanistic levels and in response to a large variety of intrinsic and extrinsic signals.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Cyclin G
  • Cyclin G1
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclin-Dependent Kinases / antagonists & inhibitors
  • Cyclin-Dependent Kinases / metabolism*
  • Cyclins / metabolism*
  • Enzyme Inhibitors / metabolism
  • Mice
  • Peptide Hydrolases / metabolism
  • Phosphorylation
  • Protein Folding


  • Ccng1 protein, mouse
  • Cdkn1a protein, mouse
  • Cyclin G
  • Cyclin G1
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclins
  • Enzyme Inhibitors
  • Cyclin-Dependent Kinases
  • Peptide Hydrolases