Cell-cycle checkpoint kinases: checking in on the cell cycle

Curr Opin Cell Biol. 2000 Dec;12(6):697-704. doi: 10.1016/s0955-0674(00)00154-x.

Abstract

In response to DNA damage, cell-cycle checkpoints integrate cell-cycle control with DNA repair. The idea that checkpoint controls are an integral component of normal cell-cycle progression has arisen as a result of studies in Drosophila and mice. In addition, an appreciation that DNA damage arises as a natural consequence of cellular metabolism, including DNA replication itself, has influenced thinking regarding the nature of checkpoint pathways.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle / physiology*
  • Cell Cycle Proteins*
  • Cell Transformation, Neoplastic / genetics
  • Checkpoint Kinase 1
  • Checkpoint Kinase 2
  • DNA Repair / physiology
  • DNA Replication / physiology
  • DNA-Binding Proteins
  • Drosophila
  • Embryo, Mammalian / enzymology
  • Embryo, Mammalian / pathology
  • Embryo, Nonmammalian / enzymology
  • Embryo, Nonmammalian / pathology
  • Genes, cdc / physiology*
  • Genetic Predisposition to Disease
  • Mice
  • Protein Kinases / genetics*
  • Protein Kinases / metabolism
  • Protein-Serine-Threonine Kinases / genetics*
  • Protein-Serine-Threonine Kinases / metabolism
  • Tumor Suppressor Protein p53 / metabolism
  • Tumor Suppressor Proteins

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Tumor Suppressor Protein p53
  • Tumor Suppressor Proteins
  • Protein Kinases
  • Atr protein, mouse
  • Checkpoint Kinase 2
  • Ataxia Telangiectasia Mutated Proteins
  • Atm protein, mouse
  • Checkpoint Kinase 1
  • Chek2 protein, mouse
  • Protein-Serine-Threonine Kinases