Genes involved in senescence and immortalization

Curr Opin Cell Biol. 2000 Dec;12(6):705-9. doi: 10.1016/s0955-0674(00)00155-1.


Senescence is now understood to be the final phenotypic state adopted by a cell in response to several distinct cell physiological processes, including proliferation, oncogene activation and oxygen free radical toxicity. The role of telomere maintenance in immortalization and the roles of p16(INK4A), p19(ARF), p53 and other genes in senescence are being further elucidated. Significant progress continues to be made in our understanding of cellular senescence and immortalization.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Division / genetics
  • Cellular Senescence / genetics*
  • Gene Expression Regulation
  • Genes, p16 / genetics
  • Humans
  • Mice
  • Oncogenes / genetics
  • Oxidative Stress / genetics
  • Proteins / genetics
  • Reactive Oxygen Species / metabolism
  • Signal Transduction / genetics
  • Telomere / genetics
  • Telomere / metabolism
  • Tumor Suppressor Protein p14ARF


  • Proteins
  • Reactive Oxygen Species
  • Tumor Suppressor Protein p14ARF