Confirmation of the genetic association of interleukin-1A with early onset sporadic Alzheimer's disease

Neurosci Lett. 2000 Oct 20;293(1):75-7. doi: 10.1016/s0304-3940(00)01487-7.


An association between altered risk of Alzheimer's disease (AD) and the interleukin-1A (IL-1A) gene was recently reported in two independent studies. Here, the IL-1A polymorphism was analyzed in a third population of 247 AD patients and 187 control individuals. In support of the published findings, the IL-1A 2/2 genotype was associated with an increased risk of early onset AD (odds ratio of 3.1, P = 0.02). Clinically, the IL-1A 2/2 genotype was associated with an earlier age of onset, but not with a change in the rate of progression of AD.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age of Onset
  • Aged
  • Alzheimer Disease / epidemiology
  • Alzheimer Disease / genetics*
  • Gene Frequency
  • Genetic Predisposition to Disease / genetics
  • Genotype
  • Humans
  • Interleukin-1 / genetics*
  • Odds Ratio
  • Polymorphism, Genetic
  • Reference Values


  • Interleukin-1