Dendritic cells: new roles for Cdc42 and Rac in antigen uptake?

Curr Biol. 2000 Oct 19;10(20):R739-41. doi: 10.1016/s0960-9822(00)00736-3.

Abstract

In dendritic cells, macropinocytosis is downregulated during maturation and antigen presentation. New studies indicate a key role for Rho-family GTPases in this regulation, but what these proteins are actually doing remains a mystery.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens / metabolism
  • Dendritic Cells / cytology
  • Dendritic Cells / physiology*
  • Humans
  • Macrophages / physiology
  • Pinocytosis
  • cdc42 GTP-Binding Protein / metabolism*
  • rac GTP-Binding Proteins / metabolism*

Substances

  • Antigens
  • cdc42 GTP-Binding Protein
  • rac GTP-Binding Proteins