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. 2000 Nov 7;97(23):12880-4.
doi: 10.1073/pnas.97.23.12880.

Effects of environmental enrichment on gene expression in the brain

C Rampon  1 , C H Jiang, H Dong, Y P Tang, D J Lockhart, P G Schultz, J Z Tsien, Y Hu
Affiliations

Effects of environmental enrichment on gene expression in the brain

C Rampon et al. Proc Natl Acad Sci U S A. .

Abstract

An enriched environment is known to promote structural changes in the brain and to enhance learning and memory performance in rodents [Hebb, D. O. (1947) Am. Psychol. 2, 306-307]. To better understand the molecular mechanisms underlying these experience-dependent cognitive changes, we have used high-density oligonucleotide microarrays to analyze gene expression in the brain. Expression of a large number of genes changes in response to enrichment training, many of which can be linked to neuronal structure, synaptic plasticity, and transmission. A number of these genes may play important roles in modulating learning and memory capacity.

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