Bronchial hyperresponsiveness in subjects with gastroesophageal reflux

Respiration. 2000;67(5):507-9. doi: 10.1159/000067464.


Background: The relationship between gastroesophageal reflux (GER) and asthma has been widely studied in the last years. GER may interfere with airway reactivity and aggravate or even induce asthma.

Objective: To assess the prevalence of bronchial hyperresponsiveness (BHR) in patients with GER disease with a view to judging the potential influence of GER on BHR.

Methods: 30 patients with GER disease and no clinical evidence of asthma and 30 normal subjects underwent a methacholine bronchial challenge. The methacholine concentration that caused a 20% fall in the FEV(1) (PC20) was used to assess bronchial responsiveness.

Results: In the GER group 11 subjects of the 30 studied showed a PC20 methacholine equal to or less than 8 mg/ml while in the control group only 2 subjects had a PC20 methacholine equal to or less than 8 mg/ml (p < 0.01; ANOVA test).

Conclusions: Subjects with GER had a greater increase in airway reactivity when inhaling methacholine compared to disease-free normal subjects.

MeSH terms

  • Adult
  • Asthma / diagnosis
  • Asthma / etiology
  • Bronchial Hyperreactivity / diagnosis
  • Bronchial Hyperreactivity / etiology*
  • Case-Control Studies
  • Female
  • Gastroesophageal Reflux / complications*
  • Humans
  • Male
  • Methacholine Chloride
  • Middle Aged
  • Prevalence


  • Methacholine Chloride